In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Garibotto V. 1,2,3, Romito L.M. 4,5, Elia A.E. 4,5, Soliveri P. 4, Panzacchi A. 2,3, Carpinelli A. 6, Tinazzi M. 7,8, Albanese A. 4,5, Perani D. 1,2,3 (2011)
  In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia.
  in Movement disorders
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Garibotto V. 1,2,3, Romito L.M. 4,5, Elia A.E. 4,5, Soliveri P. 4, Panzacchi A. 2,3, Carpinelli A. 6, Tinazzi M. 7,8, Albanese A. 4,5, Perani D. 1,2,3 (literal)

Pagina inizio

• 852 (literal)

Pagina fine

• 857 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 26 (literal)

Rivista

• Movement disorders (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Pubblicato on-line: 2 Marzo 2011 Corresponding author: D. Perani (daniela.perani@hsr.it) IF 2010: 4.480 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Division of Neuroscience, Vita-Salute San Raffaele University, Milano. 2. Division of Neuroscience, San Raffaele Scientific Institute, Milano. 3. Nuclear Medicine Unit, San Raffaele Scientific Institute, Milano. 4. Department of Neurology I, IRCCS Istituto Neurologico \"Carlo Besta\", Milano. 5. Neurology Institute, Università Cattolica del Sacro Cuore, Milano. 6. IBFM-CNR, Milano. 7. Department of Neurological and Visual Sciences, University of Verona, Verona. 8. Department of Neurology, Borgo Trento Hospital, Verona. (literal)

Titolo

• In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia. (literal)

Abstract

• Background: Preclinical and clinical evidence suggests that impaired gamma-aminobutyric (GABA) control, leading to disinhibition within the sensorimotor system, might play a role in dystonia. Aim of this study is the in vivo assessment of the GABAergic system in dystonia using positron emission tomography (PET) and 11C-flumazenil, a selective GABAA receptor ligand. Methods: Fourteen subjects with primary dystonia (9 carriers of the DYT1 mutation and 5 sporadic cases) were compared to 11 controls, using a simplified reference tissue model to measure binding potential. Results: Voxel-based analyses showed a reduction in GABAA receptor expression/affinity both in DYT1 carriers and sporadic patients in primary motor and premotor cortex, primary and secondary somatosensory cortex, and in the motor component of the cingulate gyrus. Conclusions: Dysfunction of GABAA receptors in sensorimotor systems in primary (genetic and sporadic) dystonia supports the view that lack of GABAergic control may be associated with the generation of dystonic movements. (literal)

Prodotto di

• Imaging molecolare in neuropsicofarmacologia (ME.P06.006.004) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• ASSUNTA CARPINELLI (Persona)

Insieme di parole chiave

• Keywords of "In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ASSUNTA CARPINELLI (Persona)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Imaging molecolare in neuropsicofarmacologia (ME.P06.006.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Movement disorders (Rivista)

Insieme di parole chiave di

• Keywords of "In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia." (Insieme di parole chiave)