Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Morlando M; Ballarino M; Greco P; Caffarelli E; Dichtl B; Bozzoni I. (2004)
  Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast.
  in EMBO journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Morlando M; Ballarino M; Greco P; Caffarelli E; Dichtl B; Bozzoni I. (literal)

Pagina inizio

• 2392 (literal)

Pagina fine

• 2401 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• EMBO journal (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Morlando M, Department of Genetics and Molecular Biology, Institute Pasteur Cenci-Bolognetti, University of Rome 'La Sapienza', Rome Ballarino M, Department of Genetics and Molecular Biology, Institute Pasteur Cenci-Bolognetti, University of Rome 'La Sapienza', Rome Greco P, Department of Genetics and Molecular Biology, Institute Pasteur Cenci-Bolognetti, University of Rome 'La Sapienza', Rome Caffarelli E, Institute of Molecular Biology and Pathology of CNR, University of Rome 'La Sapienza', Rome Dichtl B, Department of Cell Biology, Biozentrum, University of Basel Bozzoni I, Department of Genetics and Molecular Biology, Institute Pasteur Cenci-Bolognetti, University of Rome 'La Sapienza', Rome; Institute of Molecular Biology and Pathology of CNR, University of Rome 'La Sapienza', Rome, (literal)

Titolo

• Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast. (literal)

Abstract

• RNA polymerase II transcribes genes encoding proteins and a large number of small stable RNAs. While pre-mRNA 3'-end formation requires a machinery ensuring tight coupling between cleavage and polyadenylation, small RNAs utilize polyadenylation-independent pathways. In yeast, specific factors required for snRNA and snoRNA 3'-end formation were characterized as components of the APT complex that is associated with the core complex of the cleavage/polyadenylation machinery (core-CPF). Other essential factors were identified as independent components: Nrd1p, Nab3p and Sen1p. Here we report that mutations in the conserved box D of snoRNAs and in the snoRNP-specific factor Nop1p interfere with transcription and 3'-end formation of box C/D snoRNAs. We demonstrate that Nop1p is associated with box C/D snoRNA genes and that it interacts with APT components. These data suggest a mechanism of quality control in which efficient transcription and 3'-end formation occur only when nascent snoRNAs are successfully assembled into functional particles. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• ELISA CAFFARELLI (Unità di personale interno)
• IRENE BOZZONI (Unità di personale esterno)

Incoming links:

Autore CNR di

• ELISA CAFFARELLI (Unità di personale interno)
• IRENE BOZZONI (Unità di personale esterno)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO journal (Rivista)