http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12342
Genetic engineering of allergenes for Immunotherapy (Articolo in rivista)
- Type
- Label
- Genetic engineering of allergenes for Immunotherapy (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.2174/187152809788462608 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bonura A, and Colombo P. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Biomedicina ed Immunologia Molecolare \"Alberto Monroy\" del Consiglio Nazionale delle Ricerche, Palermo, ITALY (literal)
- Titolo
- Genetic engineering of allergenes for Immunotherapy (literal)
- Abstract
- Allergen-specific immunotherapy was introduced into clinical practice at the
beginning of the 20th century and its efficacy in seasonal allergic rhinitis has been
confirmed in many clinical studies showing that this treatment is able to prevent the
onset of new sensitizations to different allergens and reduces the development of
asthma in patients with allergic rhinitis. Progress in molecular cloning and
characterization of allergens allowed the production of single recombinant allergens
whose immunological properties were tested in vitro and in vivo demonstrating that
they retain properties resembling their natural counterpart. Several rational
approaches are being developed to improve the efficacy of SIT by reducing
immunoglobulin IgE-mediated adverse reactions. Some of these molecules have been
tested into the clinic demonstrating the feasibility of using biotechnology-derived
products as new standardized, improved and safer therapeutic compositions. (literal)
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