Oligosaccharide synthesis by glycosynthases (Articolo in rivista)

Type
Label
  • Oligosaccharide synthesis by glycosynthases (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.tibtech.2003.10.008 (literal)
Alternative label
  • Perugino G.; Trincone A.; Rossi M.; Moracci M. (2004)
    Oligosaccharide synthesis by glycosynthases
    in Trends in biotechnology (Regul. ed.); Academic Press Elsevier, Amsterdam (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Perugino G.; Trincone A.; Rossi M.; Moracci M. (literal)
Pagina inizio
  • 31 (literal)
Pagina fine
  • 37 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR, Inst Prot Biochem, I-80131 Naples, Italy; CNR, Inst Chim Biomol, I-80078 Pozzuoli, NA, Italy; Univ Naples Federico II, Dipartimento Chim Biol, I-80134 Naples, Italy (literal)
Titolo
  • Oligosaccharide synthesis by glycosynthases (literal)
Abstract
  • Oligosaccharide synthesis is becoming increasingly important to the pharmaceutical industry because these biomolecules have potential application as therapeutics. Enzymatic synthesis of oligosaccharides includes both glycosyl transferases and glycosidases. The main advantage of this approach compared with traditional chemical synthesis is the regio- and stereo-selectivity that can be achieved without the need for protecting functional groups. However, the limited availability of glycosyl transferases, the high cost of their substrates, and the poor yields of the synthetic reactions performed by the glycosidases hamper their use in the large-scale production of oligosaccharides. The recent advent of glycosynthases - specifically mutated glycosidases that efficiently synthesize oligosaccharides but do not hydrolyse them - represents a promising solution to these problems. Here, we review the most recent developments in the glycosynthase approach. (literal)
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