Order versus Disorder: in vivo bone formation within osteoconductive scaffolds (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Order versus Disorder: in vivo bone formation within osteoconductive scaffolds (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• S. Scaglione; P. Giannoni; P. Bianchini; M. Sandri; R. Marotta; G. Firpo; U. Valbusa; A. Tampieri; A. Diaspro; P. Bianco; R. Quarto (2012)
  Order versus Disorder: in vivo bone formation within osteoconductive scaffolds
  in Scientific reports (Nature Publishing Group)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• S. Scaglione; P. Giannoni; P. Bianchini; M. Sandri; R. Marotta; G. Firpo; U. Valbusa; A. Tampieri; A. Diaspro; P. Bianco; R. Quarto (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 2 (literal)

Rivista

• Scientific reports (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Advanced Biotechnology Center (CBA), Largo R. Benzi 10, 16145 Genoa, Italy IEIIT - Research National Council (CNR), Via De Marini 6, 16149 Genoa, Italy Italian Institute of Technology, Via Morego 30, 16100 Genoa, Italy ISTEC-CNR, Institute of Science and Technology for Ceramic Materials, National Research Institute, via Granarolo 64, 48018 Faenza, Italy Nanomed lab, Physics Department (DIFI), Via Dodecaneso, 33 16146 Genova and S.C. Nanobiotecnologie IST, Largo R. Benzi 10, 16132 Genoa, Italy Department of Molecular Medicine, Sapienza University of Rome, Viale regina Elena 324, 00161 Rome, Italy Department of Experimental Medicine (DIMES), University of Genoa, Largo R. Benzi 10, 16145 Genoa, Italy (literal)

Titolo

• Order versus Disorder: in vivo bone formation within osteoconductive scaffolds (literal)

Abstract

• In modern biomaterial design the generation of an environment mimicking some of the extracellular matrix features is envisaged to support molecular cross-talk between cells and scaffolds during tissue formation/remodeling. In bone substitutes chemical biomimesis has been particularly exploited; conversely, the relevance of pre-determined scaffold architecture for regenerated bone outputs is still unclear. Thus we aimed to demonstrate that a different organization of collagen fibers within newly formed bone under unloading conditions can be generated by differently architectured scaffolds. An ordered and confined geometry of hydroxyapatite foams concentrated collagen fibers within the pores, and triggered their self-assembly in a cholesteric-banded pattern, resulting in compact lamellar bone. Conversely, when progenitor cells were loaded onto nanofibrous collagen-based sponges, new collagen fibers were distributed in a nematic phase, resulting mostly in woven isotropic bone. Thus specific biomaterial design relevantly contributes to properly drive collagen fibers assembly to target bone regeneration. (literal)

Prodotto di

• Institute of science and technology for ceramics (ISTEC) (Istituto)
• Approcci innovativi al tissue engineering (INT.P02.002.004) (Modulo)
• Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni (IEIIT) (Istituto)

Autore CNR

• MONICA SANDRI (Persona)
• ANNA TAMPIERI (Persona)
• SILVIA SCAGLIONE (Persona)

Incoming links:

Prodotto

• Institute of science and technology for ceramics (ISTEC) (Istituto)
• Istituto di elettronica e di ingegneria dell'informazione e delle telecomunicazioni (IEIIT) (Istituto)
• Approcci innovativi al tissue engineering (INT.P02.002.004) (Modulo)

Autore CNR di

• ANNA TAMPIERI (Persona)
• MONICA SANDRI (Persona)
• SILVIA SCAGLIONE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Scientific reports (Rivista)