http://www.cnr.it/ontology/cnr/individuo/prodotto/ID198589

Contribution of the 9p21.3 genomic region to the pathogenesis of cerbrovascular disorders in the Italian population. (Contributo in atti di convegno)

Type

Prodotto della ricerca (Classe)
Contributo in atti di convegno (Classe)

Label

Contribution of the 9p21.3 genomic region to the pathogenesis of cerbrovascular disorders in the Italian population. (Contributo in atti di convegno) (literal)

Anno

2011-01-01T00:00:00+01:00 (literal)

Alternative label

Parolo S, Ciusani E, Gentilini D, Gori F, Lisa A, Barlera S, Di Blasio A.M, Parati E.A, Bione S, Boncoraglio G.B. (2011)
Contribution of the 9p21.3 genomic region to the pathogenesis of cerbrovascular disorders in the Italian population.
in 36 th FEBS Congress, Turin, 25-30 June 2011
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Parolo S, Ciusani E, Gentilini D, Gori F, Lisa A, Barlera S, Di Blasio A.M, Parati E.A, Bione S, Boncoraglio G.B. (literal)

Pagina inizio

369 (literal)

Pagina fine

369 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

278 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana

278 supplement 1 (literal)

Rivista

?The ?FEBS journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

1 (literal)

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S1 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institute of Molecular Genetics, National Research Council, Pavia; Neurological Institute C. Besta, Milan; Mario Negri Institute for Pharmacological Research, Milan; Istituto Auxologico Italiano, Milan. (literal)

Titolo

Contribution of the 9p21.3 genomic region to the pathogenesis of cerbrovascular disorders in the Italian population. (literal)

Abstract

Stroke is the third most common cause of death and the major cause of adult neurological disability, representing an important health issue. Cerebrovascular disorders, particularly ischemic stroke, are complex diseases in which several genetic variants interact with environmental factors to determine phenotypic manifestations. The identification of such genetic factors is essential to improve risk prediction and to gain insight into pathophysiological mechanisms and it will eventually allow the development of new therapeutic strategies. We are studying an Italian cohort of patients affected by cerebrovascular disorders: a total of 712 cases have been recruited and genotyped on the Illumina platform for more than 600k whole-genome SNPs, together with a total of 961 healthy individuals selected as controls (in part recruited in collaboration with the PROCARDIS consortium). A case-control genome-wide association study is now ongoing in order to validate previously recognized risk variant and to identify new genetic determinants. In particular we are studying the association of genetic variants at 9p21.3, a genomic region already known to be involved in the pathogenesis of different disorders, in the Italian Cerebrovascular Cohort. Results of our analysis demonstrated that genetic variants in this region represent risk factors for Cerebrovascular disorders also in the Italian population and highlighted the preferential association to the subgroup of patients affected by vascular dementia. (literal)

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