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Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? (Articolo in rivista)
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- Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? (Articolo in rivista) (literal)
- Anno
- 2001-01-01T00:00:00+01:00 (literal)
- Alternative label
Soldani C, Lazze MC, Bottone MG, Tognon G, Biggiogera M, Pellicciari CE, Scovassi AI. (2001)
Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where?
in Experimental cell research
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- Soldani C, Lazze MC, Bottone MG, Tognon G, Biggiogera M, Pellicciari CE, Scovassi AI. (literal)
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- Titolo
- Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? (literal)
- Abstract
- Poly(ADP-ribose) polymerase-1 (PARP-1) plays the active role of \"nick sensor\" during DNA repair and apoptosis, when it synthesizes ADP-ribose from NAD(+) in the presence of DNA strand breaks. Moreover, PARP-1 becomes a target of apoptotic caspases, which originate two proteolytic fragments of 89 and 24 kDa. The precise relationship between PARP-1 activation and degradation during apoptosis is still a matter of debate. In human Hep-2 cells driven to apoptosis by actinomycin D, we have monitored PARP-1 activity by the mAb 10H, which is specific for the ADP-ribose polymers, and we have observed that poly(ADP-ribose) synthesis is a very early response to the apoptotic stimulus. The analysis of the presence and fate of the p89 proteolytic fragment revealed that PARP-1 proteolysis by caspases is concomitant with poly(ADP-ribose) synthesis and that p89 migrates from the nucleus into the cytoplasm in late apoptotic cells with advanced nuclear fragmentation. Copyright 2001 Academic Press. (literal)
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