Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. (Articolo in rivista)

Type
Label
  • Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • Lindsay Fernández-Rhodes*, Ellen W. Demerath, Diana L. Cousminer, Ran Tao, Jill G. Dreyfus, Tõnu Esko, Albert V. Smith, Vilmundur Gudnason, Tamara B. Harris, Lenore Launer, Patrick F. McArdle, Laura M. Yerges-Armstrong, Cathy E. Elks, David P. Strachan, Zoltán Kutalik, Peter Vollenweider, Bjarke Feenstra, Heather A. Boyd, Andres Metspalu, Evelin Mihailov, Linda Broer, M. Carola Zillikens, Ben Oostra, Cornelia M. van Duijn, Kathryn L. Lunetta, John R. B. Perry, Anna Murray, Daniel L. Koller, Dongbing Lai, Tanguy Corre, Daniela Toniolo, Eva Albrecht, Doris Stöckl, Harald Grallert, Christian Gieger, Caroline Hayward, Ozren Polasek, Igor Rudan, James F. Wilson, Chunyan He, Peter Kraft, Frank B. Hu, David J. Hunter, Jouke-Jan Hottenga, Gonneke Willemsen, Dorret I. Boomsma, Enda M. Byrne, Nicholas G. Martin, Grant W. Montgomery, Nicole M. Warrington, Craig E. Pennell, Lisette Stolk, Jenny A. Visser, Albert Hofman, André G. Uitterlinden, Fernando Rivadeneira, Peng Lin, Sherri L. Fisher, Laura J. Bierut, Laura Crisponi, Eleonora Porcu, Massimo Mangino, Guangju Zhai, Tim D. Spector, Julie E. Buring, Lynda M. Rose, Paul M. Ridker, Charles Poole, Joel N. Hirschhorn, Joanne M. Murabito, Daniel I. Chasman, Elisabeth Widen, Kari E. North, Ken K. Ong and Nora Franceschini (2013)
    Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
    in American journal of epidemiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lindsay Fernández-Rhodes*, Ellen W. Demerath, Diana L. Cousminer, Ran Tao, Jill G. Dreyfus, Tõnu Esko, Albert V. Smith, Vilmundur Gudnason, Tamara B. Harris, Lenore Launer, Patrick F. McArdle, Laura M. Yerges-Armstrong, Cathy E. Elks, David P. Strachan, Zoltán Kutalik, Peter Vollenweider, Bjarke Feenstra, Heather A. Boyd, Andres Metspalu, Evelin Mihailov, Linda Broer, M. Carola Zillikens, Ben Oostra, Cornelia M. van Duijn, Kathryn L. Lunetta, John R. B. Perry, Anna Murray, Daniel L. Koller, Dongbing Lai, Tanguy Corre, Daniela Toniolo, Eva Albrecht, Doris Stöckl, Harald Grallert, Christian Gieger, Caroline Hayward, Ozren Polasek, Igor Rudan, James F. Wilson, Chunyan He, Peter Kraft, Frank B. Hu, David J. Hunter, Jouke-Jan Hottenga, Gonneke Willemsen, Dorret I. Boomsma, Enda M. Byrne, Nicholas G. Martin, Grant W. Montgomery, Nicole M. Warrington, Craig E. Pennell, Lisette Stolk, Jenny A. Visser, Albert Hofman, André G. Uitterlinden, Fernando Rivadeneira, Peng Lin, Sherri L. Fisher, Laura J. Bierut, Laura Crisponi, Eleonora Porcu, Massimo Mangino, Guangju Zhai, Tim D. Spector, Julie E. Buring, Lynda M. Rose, Paul M. Ridker, Charles Poole, Joel N. Hirschhorn, Joanne M. Murabito, Daniel I. Chasman, Elisabeth Widen, Kari E. North, Ken K. Ong and Nora Franceschini (literal)
Rivista
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  • Author affiliations: Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Kari E. North); Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan (John R. B. Perry); Centre for Population Health Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom (Igor Rudan, James F. Wilson); Department of Public Health, School of Medicine, University of Split, Split, Croatia (Ozren Polasek); Department of Biological Psychology, Faculty of Psychology and Education, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Jouke-Jan Hottenga, Gonneke Willemsen, Dorret I. Boomsma); Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts (Kathryn L. Lunetta); Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Ran Tao); Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia (Andres Metspalu, Tõnu Esko, Evelin Mihailov); Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands (Ben Oostra); Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark (Bjarke Feenstra, Heather A. Boyd); Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands (Cornelia M. van Duijn, Linda Broer, AlbertHofman, André G. Uitterlinden); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Lindsay Fernández-Rhodes, Charles Poole, Kari E. North, Nora Franceschini); Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Kari E. North); Department of Genetics, Harvard Medical School, Boston, Massachusetts (Joel N. Hirschhorn); Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (M. Carola Zillikens, Lisette Stolk, Fernando Rivadeneira, Jenny A. Visser, André G. Uitterlinden); Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana (Daniel L. Koller, Dongbing Lai); Department of Medical Genetics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland (Zoltán Kutalik); Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland (Laura M. Yerges-Armstrong, Patrick F. McArdle); Department of Medicine, Internal Medicine Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (Peter Vollenweider); Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts (David J. Hunter, Peter Kraft, Frank B. Hu); Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Germany (Doris Stöckl); Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri (Laura J. Bierut, Peng Lin, Sherri L. Fisher); Department of Public Health, School of Medicine, Indiana University, Indianapolis, Indiana (Chunyan He); Department of Twin Research and Genetic Epidemiology, Division of Genetics and Molecular Medicine, School of Medicine, King's College London, London, United Kingdom (John R. B. Perry, Tim D. Spector, Massimo Mangino, Guangju Zhai); Department of Biomedical Sciences, Faculty of Medicine and Surgery, University of Sassari, Sassari, Italy (Eleonora Porcu); Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada (Guangju Zhai); Division of Cell Biology, San Raffaele Scientific Institute, Milan, Italy (Tanguy Corre, Daniela Toniolo); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota (Ellen W. Demerath, Jill G. Dreyfus); Division of Genetics, San Raffaele Scientific Institute, Milan, Italy (Tanguy Corre, Daniela Toniolo); Division of Population Health Sciences and Education, St. George's Hospital Medical School, University of London, London, United Kingdom (David P. Strachan); Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts (Paul M. Ridker, Daniel I. Chasman, Julie E. Buring, Lynda M. Rose); Estonian Genome Center, University of Tartu, Tartu, Estonia (Andres Metspalu, Tõnu Esko, Evelin Mihailov); Gen Info Ltd., Zagreb, Croatia (Ozren Polasek); Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia (Enda M. Byrne, Nicholas G. Martin, Grant W. Montgomery); Genetics of Complex Traits Research Group, Peninsula Medical School, University of Exeter, Exeter, UnitedKingdom (Anna Murray, John R. B. Perry); Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Paul M. Ridker, Daniel I. Chasman, Julie E. Buring); Icelandic Heart Association, Reykjavik, Iceland (Albert V. Smith, Vilmundur Gudnason); Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (Doris Stöckl); Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (Christian Gieger, Eva Albrecht); Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland (Elisabeth Widen, Diana L. Cousminer); Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy (Laura Crisponi, Eleonora Porcu); Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland (Tamara B. Harris, Lenore Launer); MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (Cathy E. Elks, Ken K. Ong); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom (Caroline Hayward); Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, the Netherlands (M. Carola Zillikens, Cornelia M. van Duijn, Linda Broer, Lisette Stolk, André G. Uitterlinden, Fernando Rivadeneira); Netherlands Twin Register, Amsterdam, the Netherlands (Jouke-Jan Hottenga, Gonneke Willemsen, Dorret I. Boomsma); Program in Personalized and Genomic Medicine, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland (Laura M. Yerges-Armstrong, Patrick F. McArdle); Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (Harald Grallert); School of Women's and Infants' Health, University of Western Australia, Perth, Australia (Nicole M. Warrington, Craig E. Pennell); Section of General Internal Medicine, Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts (Joanne M. Murabito); Swiss Institute of Bioinformatics, Lausanne, Switzerland (Zoltán Kutalik); Complex Traits Genomics Group, Queensland Brain Institute, University of Queensland, Brisbane, Australia (Enda M. Byrne); and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom (John R. B. Perry). (literal)
Titolo
  • Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. (literal)
Abstract
  • Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970-2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9-17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development. (literal)
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