A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/srep02005 (literal)

Alternative label

• Nativi, Cristina; Gualdani, Roberta; Dragoni, Elisa; Mannelli, Lorenzo Di Cesare; Sostegni, Silvia; Norcini, Martina; Gabrielli, Gabriele; la Marca, Giancarlo; Richichi, Barbara; Francesconi, Oscar; Moncelli, Maria Rosa; Ghelardini, Carla; Roelens, Stefano (2013)
  A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain
  in Scientific reports (Nature Publishing Group)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Nativi, Cristina; Gualdani, Roberta; Dragoni, Elisa; Mannelli, Lorenzo Di Cesare; Sostegni, Silvia; Norcini, Martina; Gabrielli, Gabriele; la Marca, Giancarlo; Richichi, Barbara; Francesconi, Oscar; Moncelli, Maria Rosa; Ghelardini, Carla; Roelens, Stefano (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Rivista

• Scientific reports (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Florence; University of Florence; Dipartimento NeuroFarBa; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain (literal)

Abstract

• Neuropathic pain (NeP) is generally considered an intractable problem, which becomes compelling in clinical practice when caused by highly effective chemotherapeutics, such as in the treatment of cancer with oxaliplatin (OXA) and related drugs. In the present work we describe a structurally new compound, ADM_09, which proved to effectively revert OXA-induced NeP in vivo in rats without eliciting the commonly observed negative side-effects. ADM_09 does not modify normal behavior in rats, does not show any toxicity toward astrocyte cell cultures, nor any significant cardiotoxicity. Patch-clamp recordings demonstrated that ADM_09 is an effective antagonist of the nociceptive sensor channel TRPA1, which persistently blocks mouse as well as human variants of TRPA1. A dual-binding mode of action has been proposed for ADM_09, in which a synergic combination of calcium-mediated binding of the carnosine residue and disulphide-bridge-forming of the lipoic acid residue accounts for the observed persistent blocking activity toward the TRPA1 channel. (literal)

Prodotto di

• Istituto di metodologie chimiche (IMC) (Istituto)

Autore CNR

• STEFANO ROELENS (Persona)

Incoming links:

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• http://www.cnr.it/ontology/cnr/individuo/modulo/ID6999

Autore CNR di

• STEFANO ROELENS (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Scientific reports (Rivista)