The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests (Articolo in rivista)

Type
Label
  • The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1210/jc.2006-0019 (literal)
Alternative label
  • Brehm A., Thomaseth K., Bernroider E., Nowotny P., Waldhäusl W., Pacini G., and Roden M. (2006)
    The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests
    in The Journal of clinical endocrinology and metabolism
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Brehm A., Thomaseth K., Bernroider E., Nowotny P., Waldhäusl W., Pacini G., and Roden M. (literal)
Pagina inizio
  • 2272 (literal)
Pagina fine
  • 2278 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 91 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1,3,4,5,7 - Division of Endocrinology and Metabolism (A.B., E.B., P.N., W.W., M.R.), Department of Internal Medicine III, Medical University of Vienna, A-1090 Vienna, Austria 2,6 - Metabolic Unit (K.T., G.P.), Institute of Biomedical Engineering, I-35127 Padova, Italy 1,7 - First Medical Department (A.B., M.R.), Hanusch Hospital, A-1140 Vienna, Austria (literal)
Titolo
  • The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests (literal)
Abstract
  • Context: During insulin-modified frequently sampled iv glucose tol- erance tests (IM-FSIGT), which allow assessment of insulin action, plasma glucose can markedly decrease. Objective: This study aimed to assess the counterregulatory impact of the insulin-induced fall of glucose on minimal model-derived in- dices of insulin sensitivity (SI) and glucose effectiveness. Participants: Thirteen nondiabetic volunteers (seven males, six fe- males, aged 26 +- 1 yr, body mass index 22.1 +- 0.7 kg/m2) were studied. Design: All participants were studied in random order during IM- FSIGT (0.3 g/kg glucose; 0.03 U/kg insulin at 20 min) and during identical conditions but with a variable glucose infusion preventing a decrease of plasma glucose concentration below euglycemia (IM- FSIGT-CLAMP). Five participants additionally underwent euglyce- mic-hyperinsulinemic (1 mU kg-1 min-1) clamp tests. Results: Plasma glucose declined during IM-FSIGT to its nadir of 50 +- 3 mg/dl at 60 min in parallel to a rise (P +- 0.05 vs. basal) of plasma glucagon, cortisol, epinephrine, and GH. Glucose infusion rates of 4.6 +- 0.5 mg kg-1 min-1 between 30 and 180 min during IM-FSIGT-CLAMP prevented the decline of plasma glucose and the hypoglycemia counterregulatory hormone response. SI was approxi- mately 68% lower during IM-FSIGT (3.40 +- 0.36 vs. IM-FSIGT- CLAMP: 10.71 +- 1.06 10-4 min-1 per µU/ml, P < 0.0001), whereas glucose effectiveness did not differ between both protocols (0.024 +- 0.002 vs. 0.021 +- 0.003 min-1, P = NS). Compared with the eugly- cemic hyperinsulinemic clamp test, SI expressed in identical units from IM-FSIGT was approximately 66% (P = 0.001) lower but did not differ between the euglycemic hyperinsulinemic clamp test and the IM-FSIGT-CLAMP (P = NS). Conclusions: The transient fall of plasma glucose during IM-FSIGT results in lower estimates of SI, which can be explained by hormonal response to hypoglycemia. (literal)
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