A comparative structural and bioanalytical study of IVIG clinical lots (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A comparative structural and bioanalytical study of IVIG clinical lots (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s12033-013-9655-7 (literal)

Alternative label

• Sandomenico A.; Severino V.; Chambery A.; Foca A.; Foca G.; Farina C.; Ruvo M. (2013)
  A comparative structural and bioanalytical study of IVIG clinical lots
  in Molecular biotechnology (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sandomenico A.; Severino V.; Chambery A.; Foca A.; Foca G.; Farina C.; Ruvo M. (literal)

Pagina inizio

• 983 (literal)

Pagina fine

• 995 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84882900813&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 54 (literal)

Rivista

• Molecular biotechnology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, via Mezzocannone, 16, 80134 Naples, Italy; CIRPeB, via Mezzocannone 16, 80134 Naples, Italy; Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, via A. Vivaldi 43, 81100 Caserta, Italy; Kedrion SpA, Loc. Ai Conti, 55051 Lucca Castelvecchio Pascoli, Italy (literal)

Titolo

• A comparative structural and bioanalytical study of IVIG clinical lots (literal)

Abstract

• Intravenous immunoglobulin are important bio-therapeutics used in the replacement therapy for primary and secondary immunodeficiencies, chronic inflammatory disorders and several autoimmune haematologic disorders. Currently, a number of immunoglobulin intravenous (IVIG) products have been approved by the Food and Drug Administration (FDA) and are available commercially. It is known that small differences in the manufacturing processes as well as in the formulations may affect their clinical efficacy and tolerability. Therefore, given the complexity of the multi-step process required for the isolation of IVIG from human plasma, it is necessary to ensure a rigorous quality control of final products. We show here that a set of different bioanalytical techniques can be conveniently used to comparatively characterize, at a quantitative and qualitative level, different lots of IVIG preparations and to unveil randomly occurring impurities which can also affect the overall product stability. We have used circular dichroism, surface plasmon resonance and two-dimensional electrophoresis (2DE), and have demonstrated that this combination of bioanalytical approaches is very useful to improve the quality control of antibodies and to monitor the reliability of the IVIG manufacturing process. © 2013 Springer Science+Business Media New York. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• ANNAMARIA SANDOMENICO (Unità di personale interno)
• MENOTTI RUVO (Unità di personale interno)
• VALERIA SEVERINO (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "A comparative structural and bioanalytical study of IVIG clinical lots" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR di

• MENOTTI RUVO (Unità di personale interno)
• ANNAMARIA SANDOMENICO (Unità di personale interno)
• VALERIA SEVERINO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular biotechnology (Rivista)

Insieme di parole chiave di

• Parole chiave di "A comparative structural and bioanalytical study of IVIG clinical lots" (Insieme di parole chiave)