Botulinum toxin in gastric submucosa reduces stimulated HCl production in rats (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Botulinum toxin in gastric submucosa reduces stimulated HCl production in rats (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Runfola, M.; Rossi, S.; Panunzi, S.; Spada, P.L.; Gui, D. (2003)
  Botulinum toxin in gastric submucosa reduces stimulated HCl production in rats
  in Gastroenterology (N.Y.N.Y., 1943)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Runfola, M.; Rossi, S.; Panunzi, S.; Spada, P.L.; Gui, D. (literal)

Pagina inizio

• 26 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Rivista

• Gastroenterology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Botulinum toxin in gastric submucosa reduces stimulated HCl production in rats (literal)

Abstract

• (BMC. Gastroenterol) BACKGROUND: Botulinum toxin blocks acetylcholine release from nerve endings and acts as a long term, reversible inhibitor of muscle contraction as well as of salivary, sweat gland, adrenal and prostatic secretions. The aim of the present study is to investigate whether gastric submucosal injection of botulinum toxin type A reduces stimulated gastric production of HCl. METHODS: Sixty-four rats were randomized in two groups and laparotomized. One group was treated with botulinum toxin-A 10 U by multiple submucosal gastric injections, while the second group was injected with saline. Two weeks later, acid secretion was stimulated by pyloric ligation and acid output was measured. Body weight, food and water intake were also recorded daily. RESULTS: HCl production after pyloric ligation was found to be significantly lower in botulinum toxin-treated rats (657 +/- 90.25 micromol HCl vs. 1247 +/- 152. P = 0.0017). Botulinum toxin-treated rats also showed significantly lower food intake and weight gain. CONCLUSIONS: Botulinum toxin type A reduces stimulated gastric acidity. This is likely due either to inhibition of the cholinergic stimulation of gastric parietal cells, or to an action on the myenteric nervous plexuses. Reduction of growth and food intake may reflect both impaired digestion and decreased gastric motility. (literal)

Prodotto di

• Istituto di analisi dei sistemi ed informatica \"Antonio Ruberti\" (IASI) (Istituto)
• Modelli e Metodi Matematici in Fisiopatologia (ME.P06.002.001) (Modulo)

Autore CNR

• DANIELE GUI (Persona)
• SIMONA PANUNZI (Unità di personale interno)

Incoming links:

Autore CNR di

• SIMONA PANUNZI (Unità di personale interno)
• DANIELE GUI (Persona)

Prodotto

• Istituto di analisi dei sistemi ed informatica \"Antonio Ruberti\" (IASI) (Istituto)
• Modelli e Metodi Matematici in Fisiopatologia (ME.P06.002.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gastroenterology (Rivista)