Cognitive dysfunction in dysmetabolic obesity and diabetes: role of inter-organic crosstalk and cellular ageing (DSB.AD003.083)

Thematic area

Biomedical sciences

Project area

Structure responsible for the research project

Institute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS)

Project manager

CLAUDIA MIELE
Phone number: 0817463248
Email: c.miele@ieos.cnr.it

Abstract

Obesity and its comorbidities, in particular type 2 diabetes (T2D), represent widespread health threats, exhibiting increasing prevalence and challenges for patients and healthcare systems. These metabolic disorders may interact to affect cognitive function, not only in the elderly but also in the middle-aged population, as a 1.5/2-fold increase in the prevalence of mild cognitive impairment or dementia is seen among obese/T2D patients. This suggests common mechanisms perpetuated by dysmetabolic conditions that contribute to cognitive decline. Recent studies link adipose tissue- and skeletal muscle-derived substances with cognitive function, as in the case of irisin, a myokine with neuroprotective properties. Of note, while obesity and diabetes are preventable, cognitive dysfunctions are not yet.
This project stems from the hypothesis that dysfunctional adipose tissue and skeletal muscle in obese (particularly sarcopenic)/T2D individuals release substances that negatively influence brain cognitive function and/or fail to release other substances that may promote brain health Identifying and characterizing such players may be key to understand the link between obesity/sarcopenia/T2D

Goals

xxx

Start date of activity

01/01/2022

Keywords

diabetes, ageing, obesity

Last update: 26/11/2024