INCIPIT-INtegrated Conductive and biomimetic polymeric Interfaces able to serve as micronanostructured Patches for myocardIal regeneraTion (DCM.AD007.025)
Area tematica
Scienze chimiche e tecnologie dei materiali
Area progettuale
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Struttura responsabile del progetto di ricerca
Istituto per i processi chimico-fisici (IPCF)
Responsabile di progetto
CATERINA CRISTALLINI
Telefono: 0502217802
E-mail: caterina.cristallini@cnr.it
Abstract
The leading cause of death for cardiovascular disease is coronary herat disease. Current therapies do not restore the functionality of damaged myocardial tissue. The only effective therapeutic intervenction is an approach able to stimulate the autonomous regeneration of myocardium. Recently we developed bioartificial scaffolds with the potential to serve as acellular patches for in vivo cardiac regeneration. Herein, the patch will be implemented with electroconductive polymers in order to improve cardiac commitment. The protection against ventricular remodelling and recruitment of stem cells in situ will be pursued through nanotechnologies. The therapeutic product will be validated in vitro using stem and precursor cells, induced pluripotent stem cells, organotypic heart cultures and in vivo using a small model. The INCIPIT cardiac patch technology will move this material-based product closer to the market of smart therapies in the cardiovascular field.
Obiettivi
The specific objectives of this project will be addressed to:
micro-nanostructured polymeric patches;
advanced in vitro validation;
in vivo implant;
translation strategy.
Data inizio attività
29/01/2018
Parole chiave
patch, myocardial, regeneration
Ultimo aggiornamento: 28/01/2025