HOTSOLUTE (DCM.AD004.071)

Area tematica

Scienze chimiche e tecnologie dei materiali

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC)

Responsabile di progetto

DANIELA MONTI
Telefono: 0228500025
E-mail: daniela.monti@icrm.cnr.it

Abstract

This ERA-CoBiotech project is developing thermophilic in vitro enzyme cascades as well as two new chassis, the thermophilic bacterium Thermus thermophilus (Tth, 65-75°C, pH 7.0) and the thermoacidophilic archaeon Sulfolobus acidocaldarius (Saci, 75-80°C, pH 2-4), as new thermophilic, bacterial and archaeal platforms for the in vivo production of novel high added-value products. These include 'extremolytes' that are small molecular compatible solutes found naturally in the cells of thermophilic species. Extremolytes possess great potential for application in the food, health care consumer care and cosmetics market, but cannot be produced in current mesophilic production hosts. Specifically, the development of the newly designed 'cell factories' and cascades will be used for the production of three extremolytes, cyclic 2,3 di-phosphoglycerate (cDPG), di-myo-1,1'-inositol-phosphate (DIP) and mannosylglycerate (MG).

Data inizio attività

01/03/2018

Parole chiave

extremolytes, enzyme cascades, cell factories

Ultimo aggiornamento: 20/05/2024