THERmoablation of Melanoma and mammary carcinoma with Injected NAnoplarticles coupled TO Radiotherapy (THERMINATOR) (DIT.AD002.133)
Area tematica
Ingegneria, ICT e tecnologie per l'energia e i trasporti
Area progettuale
Nanotecnologie e materiali avanzati (DIT.AD002)Struttura responsabile del progetto di ricerca
Istituto di fisica applicata "Nello Carrara" (IFAC)
Responsabile di progetto
FULVIO RATTO
Telefono: 0555225307
E-mail: f.ratto@ifac.cnr.it
Abstract
This project is based on the following data: ECFCs uptake AuNPs (AuNP-ECFC) and privilege homing within tumors. In contrast to what happens by injecting bare NPs, viable Au-ECFCs remain within tumors for several weeks. The accumulation and biodistribution of AuNP-ECFCs can be followed in vivo by the novel photoacoustic imaging (PAI), which allows to achieve maximun sensitivity and specificity for the detection of tumor mass and of macro/micro-metatases in experimental animal models. AuNP-ECFCs display excellent thermotransductive properties that kill cancer cells in vitro upon laser irradiation at moderate NIR light intensities and induce necrotization of experimental tumors in mice inoculated with AuNP-ECFCs. These results led to the patent n. 102016000045932 deposited on May 04th 2016.
Data inizio attività
01/01/2020
Parole chiave
a, b, c
Ultimo aggiornamento: 28/07/2024