PhotoDyn - Unraveling the role of cell-cell communication in the photodynamic therapy of cancer (DSB.AD008.578)

Area tematica

Scienze biomediche

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di Biochimica e Biologia Cellulare (IBBC)

Responsabile di progetto

FABIO MAMMANO
Telefono: 0690091
E-mail: fabio.mammano@cnr.it

Abstract

Cell-cell communication can either promote or prevent cell death by apoptosis. Such effects may be due to the gap junction-mediated intercellular passage of survival or death signals such as Ca2+, IP3 and cAMP. Moreover, paracrine signaling mediated by connexin hemichannels may exchange proapoptotic and survival factors between extracellular and intracellular environments. In this project, we will investigate the role played by cell-cell communication in the spreading of apoptotic signals triggered by photodynamic therapy of cancer using a combination of in vitro and in vivo biophysical methods. Specifically, we will use a panel of fluorescent biosensors in combination with multiphoton microscopy to unravel the mechanisms that promote tumor cell death following activation of photosensitizer molecules.

Data inizio attività

01/01/2020

Parole chiave

tumor, cell death, photosensitizer molecules

Ultimo aggiornamento: 24/03/2025