CARIPLO SILVA 2020-3632 - Tracing the brain circuits underlying traumatic memory attenuation (DSB.AD004.344)
Area tematica
Area progettuale
Neuroscienze (DSB.AD004)Struttura responsabile del progetto di ricerca
Responsabile di progetto
BIANCAAMBROGINA SILVA
Telefono: 0282245254
E-mail: bianca.silva@in.cnr.it
Abstract
How can long-lasting traumatic memories be overcome? In this project, I propose to unravel the neural circuits underlying the attenuation of remote memories of traumatic events. To address this issue, I will undertake an innovative approach based on recently developed tools for the identification and manipulation of specific neuronal ensembles, which will allow us to analyze the cellular mechanisms as well as the brain functional connectivity at the basis of the attenuation of remote fear memories in a mouse model of post traumatic stress disorder.
Fear is an essential emotion for survival that can generate some of the most robust forms of memory. Because of this characteristic, fear can also generate some of the most harmful memories, namely when fear is experienced excessively and repeatedly. Then, fearful memories become maladaptive, resulting in post-traumatic stress disorder. Remarkably, despite the growing prevalence of such disorders, identifying effective treatments against traumatic memories has proven difficult. This discrepancy is particularly evident for remote forms of traumata, which arise when the traumatic insult cannot be promptly addressed.
Data inizio attività
01/09/2021
Parole chiave
post-traumatic stress, memory, fear
Ultimo aggiornamento: 20/05/2024