Cognitive dysfunction in dysmetabolic obesity and diabetes: role of inter-organic crosstalk and cellular ageing (DSB.AD003.083)

Area tematica

Scienze biomediche

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto per l'endocrinologia e l'oncologia "Gaetano Salvatore" (IEOS)

Responsabile di progetto

CLAUDIA MIELE
Telefono: 0817463248
E-mail: c.miele@ieos.cnr.it

Abstract

Obesity and its comorbidities, in particular type 2 diabetes (T2D), represent widespread health threats, exhibiting increasing prevalence and challenges for patients and healthcare systems. These metabolic disorders may interact to affect cognitive function, not only in the elderly but also in the middle-aged population, as a 1.5/2-fold increase in the prevalence of mild cognitive impairment or dementia is seen among obese/T2D patients. This suggests common mechanisms perpetuated by dysmetabolic conditions that contribute to cognitive decline. Recent studies link adipose tissue- and skeletal muscle-derived substances with cognitive function, as in the case of irisin, a myokine with neuroprotective properties. Of note, while obesity and diabetes are preventable, cognitive dysfunctions are not yet.
This project stems from the hypothesis that dysfunctional adipose tissue and skeletal muscle in obese (particularly sarcopenic)/T2D individuals release substances that negatively influence brain cognitive function and/or fail to release other substances that may promote brain health Identifying and characterizing such players may be key to understand the link between obesity/sarcopenia/T2D

Obiettivi

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Data inizio attività

01/01/2022

Parole chiave

diabetes, ageing, obesity

Ultimo aggiornamento: 28/07/2024