H2020 PREMSTEM Brain injury in the premature born infant: stem cell regeneration research network Dott.ssa VERDERIO (DSB.AD004.276)
Area tematica
Area progettuale
Neuroscienze (DSB.AD004)Struttura responsabile del progetto di ricerca
Responsabile di progetto
CLAUDIA VERDERIO
Telefono: 0250317098
E-mail: claudia.verderio@in.cnr.it
Abstract
This project will provide new knowledge regarding the best regimen, timing, dose, and route of administration of
human mesenchymal stem cells (H-MSC) for regenerating the brain damage in infants born preterm; born before
37 of a typical 40 weeks of gestation. Over 15 million babies are born preterm every year it is a leading cause of
death and permanent disability, often due to brain damage. The H-MSC that we will comprehensively screen are
FDA-approved and in the process of being produced in a GMP grade, making them suitable for future clinical trials
in human preterm born infants. These H-MSC will be evaluated in a large number of rodent models mimicking
the key insults and brain damage observed in human preterm infants who will develop later motor, cognitive, and
behavioral deficits. We will also apply theseH-MSC in two sheep models of injury relevant to brain damage associated
with preterm birth. These large animal trials are a key step before initiating clinical trials in this high risk human
population. Additional Workpackages will address the mechanisms underlying the regenerative effects of these HMSC.
This project addresses the call text by value adding to current knowledg
Data inizio attività
01/01/2020
Parole chiave
regenerative medicine, stem cell therapy, neuroprotection
Ultimo aggiornamento: 17/05/2025