Ricerca Finalizzata "Early treatment of exercise induced pulmonary ipertension in systemic sclerosis"- Dr.ssa Luna Gargani (DSB.AD002.038)

Area tematica

Scienze biomediche

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di fisiologia clinica (IFC)

Responsabile di progetto

LUNA GARGANI
Telefono: 0503152216
E-mail: luna.gargani@ifc.cnr.it

Abstract

Patients with systemic sclerosis (SSc) are at risk of developing pulmonary arterial hypertension (PAH), which affects their prognosis. PAH is often diagnosed late, when therapies are no longer effective. Exercise-Doppler echocardiography (EDE) enables a non-invasive identification of stress-induced increase in pulmonary artery systolic pressure (PASP), an early pre- clinical phase anticipating resting PAH.
Two-hundred SSc patients without overt PAH will undergo EDE. Patients with increased PASP and pulmonary vascular resistance at peak stress will undergo exercise right heart catheterization to confirm the diagnosis. They will then be started on endothelin receptor antagonists (ERA) and enter a strict follow-up program. Endothelial progenitor cells and circulating endothelial cells will also be evaluated and correlated to clinical and instrumental data.
Our aim is to demonstrate that EDE may identify patients with PAH at a very early stage, when ERA can be effective to prevent overt PAH

Data inizio attività

01/01/2014

Parole chiave

Prevention of immune-mediated diseases: identification of at-risk populations, immuno-epidemiology, Systemic sclerosis, Pulmonary arterial hypertension

Ultimo aggiornamento: 20/05/2024